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Re: total knee replacement
HARPAL SINGH SELHI 03 Декабрь 2004, 03:35
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please review ur reply to no 5 as cefuroxime is not used in bone cement as far as I know
Harpal
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Re: total knee replacement
Отправитель: Anton Vakulenko 03 Декабрь 2004, 03:36
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Cefuroxime could be manually mixed with cement. In fact, many surgeons do so. But I wonder how it would (or wouldn't) change mechanical properties of cement? And how the heat during polymerization would
change antimicrobial activity of cefuroxime?
--
Sincerely yours,
Anton V. Vakulenko
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Re: total knee replacement
Отправитель: HARPAL SINGH SELHI 03 Декабрь 2004, 03:37
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it does not change the antimicrobial activity of the cefuroxime but destroys the molecule as
this molecule is not heat stable.
Harpal
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Re: total knee replacement
Отправитель: Anton Vakulenko 03 Декабрь 2004, 03:38
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In other words, if molecules of cefuroxime (or any other heat unstable antibiotic) are destroyed by heat then its antimicrobial activity disappears.
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Re: total knee replacement
Отправитель: HARPAL SINGH SELHI 03 Декабрь 2004, 03:38
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of course, if the molecule does not exist how can it have its properties!!!!!!!
Harpal
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